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consequently, its discussion has been trimmed and moved to Future Directions, explicitly acknowledging the absence of clinical evidence and the PK uncertainties (dose, timing, BBB penetration, and formulation effects) relevant to rapid ascent scenarios

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In a randomized controlled trial, leukemia patients undergoing bone marrow transplant, preceded by high-dose chemotherapy, were given 100 mg/kg N-acetyl cysteine (NAC) or placebo daily for 15 days after the procedure